Adenomatoid odontogenic tumor aot is an uncommon nonaggressive tumor of the odontogenic epithelium. It is termed as aot in short and represents 3% to 7% of all odontogenic tumors. Odontogenic tumours are rare lesions and many nonspecialist histopathologists will not have seen many during their working lifetime. Extrafollicular adenomatoid odontogenic tumor a case report thomas ninan, nishath khanum, prathibha rani rm and srisha basappa oral medicine and radiology, farooqia dental college and hospital, mysore, india case report abstract the adenomatoid odontogenic tumor aot is a benign, nonneoplastic lesion with a slow but progressive growth. The third case of the same previous combination has been reported in 19868. In the past years, an unusual variant of ameloblastoma presenting histological characteristics that overlap those observed in. Tumour or a cyst, a histopathological support for the controversy. Adenomatoid odontogenic tumor aot is a benign epithelial tumor that shows duct. Pdf follicular adenomatoid odontogenic tumor semantic. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often. Current concepts and occurrence of epithelial odontogenic. Which of the following scenarios represents the most common set of clinical features associated with the follicular variant of adenomatoid odontogenic tumor aot. Adenomatoid odontogenic tumor with impacted mandibular.
Benign odontogenic tumors are divided into three types based on the presence absense of odontogenic epithelium or ectomesenchyme. Sixtynine percent of adenomatoid odontogenic tumours are diagnosed in the second decade of life, and more than half occur during the. Extrafollicular adenomatoid odontogenic tumor a case. Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery. Current medical research has not established a way of preventing adenomatoid tumor formation. An unusual primary adenomatoid tumour arising in the normal liver is described. Benign odontogenic tumors epithelial lacking evidence of inductive change tumors in this category do not show odontogenic mesenchyme or its principal product, dentine, and are represented by ameloblastoma, squamous odontogenic tumor, calcifying epithelial odontogenic tumor pindborg tumor and adenomatoid odontogenic tumor.
In the past, this tumor has been referred to as adenoameloblastoma or ameloblastic adenomatoid tumor. Histopathology of the cyst associated classification of the cyst associated follow up. Thus, the aim of this study was to perform a retrospective analysis in a case series of aot, with emphasis on the histopathological features. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Adenomatoid definition of adenomatoid by medical dictionary.
Two thirds of the cases are associated with an impacted tooth usually being the canine. Adenomatoid odontogenic tumor a report of two cases with histopathology correlation year. Adenomatoid tumors rarely involve the testicular parenchyma and are the most common paratesticular tumor. The histological features, histogenesis, and suggested treatment were discussed in their report at that time. This epithelial tumor has an inductive effect on the odontogenic ectomesenchyme with dentinoid frequently being produced. It is predominantly found in young and female patients, located more often in the. The who histological typing of odontogenic tumors, jaw cyst and allied lesions 2005 has defined aot as a tumor of odontogenic epithelium with ductlike structures and with varying degree of inductive changes in the.
Odontogenic tumours can pose significant diagnostic challenges for the pathologist because of their relatively low incidence, somewhat overlapping histology and subtle differentiating features. Adenomatoid odontogenic tumor aot is a relatively uncommon distinct odontogenic neoplasm that was first described by steensland in 1. Two thirds of cases are located in the anterior maxilla, and one third are present in the anterior mandible. It is a tumor composed of odontogenic epithelium in a variety of histoarchitectural patterns which are embedded in a mature. Not only does aot predominantly present radiologically as a unilocular cystic lesion enclosing the unerupted tooth which is commonly mistaken as a. Adenomatoid odontogenic tumor aot is a relatively rare and distinct odontogenic tumor that is exclusively odontogenic epithelium in origin.
Adenomatoid odontogenic tumor aot is an uncommon benign odontogenic. Adenomatoid odontogenic tumor aot is a relatively rare and distinct. Histopathological insight of an adenomatoid odontogenic. Clinical, radiographical and histopathological evaluation 37 pindborg tumor. Article pdf available september 2014 with 754 reads how we measure reads.
Case report dentigerous cyst or adenomatoid odontogenic. Adenomatoid odontogenic tumor aot is a benign neoplasm of odontogenic epithelium. Despite similar histologies, the biological behaviour and appropriate therapy differ significantly between entities and accurate diagnosis is therefore essential. It is well known for its unique histopathologic features, predilection for young individuals, and innocuous behavior. Pdf adenomatoid odontogenic tumor aot is an uncommon, hamartomatous, benign, epithelial lesion of odontogenic origin that was first described by. Odontogenic tumors are both benign and malignant and have been classified accordingly by who in 1992 which was further divided into sub divisions by white dk in 2004. Adenomatoid definition of adenomatoid by the free dictionary. Pdf histopathological insight of an adenomatoid odontogenic. The adenomatoid odontogenic tumor is an odontogenic tumor arising from the enamel organ or dental lamina. Histopathology revealed cuboidal to columnar cells arranged in the form of nests and.
Here we are reporting a case of adenomatoid odontogenic tumor in a 16yearold female patient in the maxillary region. Although considerable number of reports is available with regard to the clinical and histological spectrum of aot, very few. Discussion adenomatoid odontogenic tumour is a slowly growing lesion, with a predilection for the anterior maxilla ratio of cases 2. Outcomesresolutions the prognosis of adenomatoid tumors is very good, even if they infiltrate extend into adjacent structures. The patient has shown no signs of recurrence after eleven months of follow up period. Pathology of adenomatoid tumour dr sampurna roy md. Adenomatoid odontogenic tumor aot formerly called an adenoameloblastoma, a somewhat deceptive term that should be discarded, the aot represents about 37 % of all odontogenic tumors. Adenomatoid odontogenic tumor is a rare benign and odontogenic tumor that is frequently misdiagnosed as other odontogenic cysts and tumors on radiographic examination. Pdf adenomatoid odontogenic tumor aot is a epithelial tumor with an inductive. Case report souza rs1, silva jbp2, villalba h3, santos cc4, georgevich neto r5 and giovani em6 1coordinator of the dentistry course at paulista university sorocaba and professor of the disciplines of oral diagnosis.
Kubleradenomatoid odontogenic tumor of the mandible. Aots tend to be encapsulated but produce a variety of architectural patterns, most notably multiple, variably sized nodules of polyhedral to spindled epithelial cells with minimal stroma. Current concepts of odontogenic tumours diagnostic. The adenomatoid odontogenic tumor aot is included in. Rightfully called the master of disguise, this lesion has been known for its varied clinical and histoarchitectural patterns.
Adenomatoid odontogenic tumor aot is an uncommon benign epithelial lesion of odontogenic origin and, thus far, only few studies regarding the frequency of its many histopathologic features have been published in the literature. Review of the literature and first expression and mutational analysis of. Keywords adenomatoid odontogenic tumor odontogenic tumor clinical histopathology introduction adenomatoid odontogenic tumor aot is an uncommon benign epithelial lesion of odontogenic origin, representing approximately 3. Adenomatoid odontogenic tumor histological, radiological. Expression of ck14 and vimentin in adenomatoid odontogenic. The patient presentation of a small painless mass in a patient in the third fourth decade is typical. Ameloblastoma and adenomatoid odontogenic tumor suk keun lee yeon sook kim1 department of oral pathology, college of dentistry, gangneungwonju national university, gangneung. Pdf odontogenic tumors are a group of heterogeneous lesions, features of which have been catalogued for several decades. Histological examination revealed cystic or angiomatoid spaces of various sizes lined by cuboidal, lowcolumnar. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. This lesion is categorised into three variants of which the more common variant is follicular type which is often mistaken for dentigerous cyst. Odontogenic keratocysts make up around 19% of jaw cysts. Anterior mandible, unerupted central incisor tooth, elderly male anterior maxilla, unerupted canine tooth, teenage female.
Clinical radiological and histopathological dilemma shiveshacharya, 1 ashimagoyal, 1 vidyarattan, 2 kimvaiphei, 3 andsarabjotkaurbhatia 1 department of pediatric and preventive dentistry, oral health sciences center. Adenomatoid tumour is a relatively uncommon, benign neoplasm of mesothelial origin that is usually confined to the male and female genital tracts located in the myometrium, fallopian tube, ovary, epididymis, tunica albuginea, and testicular parenchyma. Adenomatoid odontogenic tumor is an uncommon odontogenic lesion, composed of odontogenic epithelium, characterized histologically by duct like structures with amyloid like deposits, noninvasive lesion with slow but progressive growth. However when the ameloblastoma shows a typical expansile multilocular aspect, the differential diagnosis can include a variety of odontogenic or nonodontogenic lesions with similar characteristics like odontogenic keratocysts, aneurysmal bone cysts, adenomatoid odontogenic tumors, odontogenic myxomas, and giant cell central lesions. It is considered as a hamartoma rather than a true neoplasm because of slow growth and circumscription of the lesion. This is an adenomatoid tumor, which is of mesothelial origin as the staining pattern suggests. Adenomatoid odontogenic tumor with its simple abbreviation aot is the most widely accepted terminology philipsen and birn, 1969. Histopathology revealed intraosseus follicular variant of aot. The adenomatoid odontogenic tumor aot is a rare, slow growing, benign, odontogenic epithelial tumor with characteristic clinical and histological features. Pdf what in the past had been referred to as adenomatoid odontogenic tumor aot is now recognized to consistently represent a lumen. They are also seen more frequently in females, most frequently in the second decade of life. They are the most common extratesticular neoplasm, and most common tumor of the epididymis, and occur more often in the lower pole than in the upper pole by a. The diagnosis of adenomatoid odontogenic tumor should be considered in a case with a corticated radiolucency in the anterior jaw, especially in teens and young adults. To acquire additional information of adenomatoid odontogenic tumor, we performed magnetic resonance imagings mri at a case of adenomatoid odontogenic tumor.
A manual search of all related oral pathology, maxillofacial and specialist dental and oral journals was performed. Adenomatoid odontogenic tumor aot is an uncommon benign odontogenic lesion that affects young patients associated with an impacted tooth, usually canine. Immunohistological features in adenomatoid odontogenic tumor. Adenomatoid odontogenic tumor was formerly considered to be a variant of aneloblastoma and was called as adenoamelobalstoma. Grossly, the tumour showed a haemorrhagic cut surface with numerous microcystic structures. This article covers odontogenic tumours and cysts, which is a subset of oral pathology and can be grouped under the heading of head and neck pathology the general topic of head and neck pathology is covered in the head and neck pathology and head and neck cytopathology articles the vast majority of oral malignancies are squamous cell carcinoma. Adenomatoid tumors of the scrotum radiology reference. Adenomatoid tumors of the scrotum are benign, solid extratesticular lesions that can originate from the epididymis, tunica vaginalis, or spermatic cord 90% derived from the funiculus.
Immunohistological features in adenomatoid odontogenic. Case report dentigerous cyst or adenomatoid odontogenic tumor. Adenomatoid tumour of the liver journal of clinical. Adenomatoid odontogenic tumor aot is a wellrecognised slow growing benign tumor derived from complex system of dental lamina or its remnants. The adenomatoid odontogenic tumor aot is a rare benign odontogenic lesion, that is slowgrowing and noninvasive, although few aggressive cases have been reported. Adenomatoid odontogenic tumor aot is a wellestablished benign epithelial lesion of odontogenic origin.
Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Adenomatoid odontogenic tumor oral and maxillofacial surgery. Aot had been initially described and classified as adenomaoid variant of the ameloblastoma and has been recognized as a distinct lesion only since unerupted. Whether it was dentigerous cyst transforming to adenomatoid tumor or a cystic variant of adenomatoid odontogenic tumor in the present case could not be stated with exactitude as initially to preserve associated tooth only part of cystic lining was removed for histopathological evaluation. Adenomatoid odontogenic tumors are rare and differ from most other dentition related lesions in that they more frequently occur in the maxilla epidemiology. D, frcpath assistant prof of general pathology senior lecturer of oral pathology and oral histology. Adenomatoid odontogenic tumor a rare cause of jaw swelling. Current concepts and occurrence of epithelial odontogenic tumors. Adenomatoid odontogenic tumor of the mandible with. Histopathological insight of an adenomatoid odontogenic lesion a cyst, tumor or hamartoma.
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